Mr. Show with Bob and David is an American sketch comedy series starring and hosted by Saturday Night Live writer/actor Bob Odenkirk and stand up comedian/actor David Cross. It aired on HBO from November 3, 1995 to December 28, 1998.

Cross and Odenkirk introduced most episodes as heightened versions of themselves, before transitioning to a mixture of live sketches and pre-taped segments. The show featured a number of alternative comedians as both cast members and writers, including Sarah Silverman, Paul F. Tompkins, Jack Black, Tom Kenny, Mary Lynn Rajskub, Brian Posehn, Jerry Minor, Scott Aukerman, and Dino Stamatopoulos.

It was nominated for four Primetime Emmy Awards, as well as a Golden Satellite Award.